Once you've filtered out all the data you absolutely don't need going into a database but still find the database is unusably large there is the option to tune integer bits and field length. However the problem with tuning on such a massive database is knowing how much is in each database field already.
I'd like to see in each database field next to the Field Length and Integer Bits options a number in brackets which indicates the largest length item or number of bits stored respectively of the current database. This way tuning these options can be done much quicker and in an informed way.
Not sure if its possible, but adding more bit options could also help a lot (eg 24 and 48 bits).